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糖尿病及内分泌病学学术中心

二肽基肽酶-4 (DPP-4) 抑制剂的作用机制

Mechanism of action of inhibitors of dipeptidyl-peptidase-4 (DPP-4)

来源: 发布时间:2014-3-21
作者:Nancy A. Thornberry, Baptist Gallwitz
期刊: BEST PRACT RES CL EN 2009年8月4期23卷

Dipeptidyl-peptidase IV (DPP-4) inhibitors inhibit the degradation of the incretins, glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP). The first available DPP-4 inhibitors are sitagliptin and vildagliptin. These compounds are orally active and have been shown to be efficacious and well tolerated. Two additional DPP-4 inhibitors are under review, and there are several others in clinical development. This article gives an overview on the mechanism of action of DPP-4 inhibitors and focuses on their development and their important physiological actions with regard...

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