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糖尿病及内分泌病学学术中心

多发性硬化症:雌激素-孕酮与性别的神经保护联盟

Multiple sclerosis: Neuroprotective alliance of estrogen–progesterone and gender

来源: 发布时间:2012-2-24
作者:Markus Kipp, Sandra Amor, Raphael Krauth, Cordian
期刊: FRONT NEUROENDOCRIN 2012年2月1期33卷

Abstract
The potential of 17β-estradiol and progesterone as neuroprotective factors is well-recognized. Persuasive data comes from in vitro and animal models reflecting a wide range of CNS disorders. These studies have endeavored to translate findings into human therapies. Nonetheless, few human studies show promising results. Evidence for neuroprotection was obtained in multiple sclerosis (MS) patients. This chronic inflammatory and demyelinating disease shows a female-to-male gender prevalence and disturbances in sex steroid production. In MS-related animal models, steroids ameliorate symptoms and protect from demyelination and neuronal damage. Both hormones operate in dampening centra

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